Redigerer Sesongavhengig depresjon (avsnitt)

=== Antidepressiva ===
{{Hoved|Antidepressiva}}
SSRI (selektive serotoninreopptakshemmer) antidepressiva har vist seg å være effektive i behandlingen av SAD. Bupropion kan også virke forebyggende.<ref name="Modell"/> Effektive antidepressiva er fluoksetin sertralin eller paroksetin.<ref name="Lam"/><ref>{{cite journal |last = Moscovitch |first = A | coauthors = Blashko CA, Eagles JM, Darcourt G, Thompson C, Kasper S, Lane RM |title = A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder |url = https://archive.org/details/sim_psychopharmacology_2004-02_171_4/page/390 |journal = Psychopharmacology |volume = 171 |year = 2004 |pages = 390–7 |doi = 10.1007/s00213-003-1594-8 |pmid = 14504682 |author8 = International Collaborative Group on Sertraline in the Treatment of Outpatients with Seasonal Affective Disorders |issue = 4}}</ref> Ifølge et sammenlignende forsøk gjennomført i løpet av 2006 i Can-SAD-studien, er både fluoksetin og lysterapi 67% effektive i behandlingen av SAD.<ref>{{cite journal | last = Lam | first = Raymond W. | coauthors = Anthony J. Levitt, Robert D. Levitan, et al. | year = 2006 | month = May | title = The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder | journal = Am J Psychiatry | volume = 163 | issue = 163 | pmid = 16648320 | pages = 805–812 | doi = 10.1176/appi.ajp.163.5.805 | url = http://day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf | format = PDF | url-status = dead | archiveurl = https://www.webcitation.org/5sSzQgPfj?url=http://day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf | archivedate = 2010-09-03 | tittel = Arkivert kopi | besøksdato = 2008-09-30 | arkivurl = https://www.webcitation.org/5sSzQgPfj?url=http://day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf | arkivdato = 2010-09-03 | url-status=død }} {{Kilde www |url=http://day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf |tittel=Arkivert kopi |besøksdato=2010-09-24 |arkiv-dato=2009-11-27 |arkiv-url=https://web.archive.org/web/20091127151319/http://www.day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf |url-status=yes }}</ref> Pasienter som brukte lysterapi viste raskere klinisk bedring, vanligvis innen en uke etter oppstarten av behandlingen.<ref name="Lam"/>